Five Liga MX fixtures hit Thursday with sharp parlay value on offer. Here are the best combinations and standout odds from FanDuel.
Liga MX Thursday Parlay Guide – April 23, 2026
Five Liga MX matches light up Thursday's slate, and the FanDuel board is serving up some genuinely interesting prices. Whether you're looking for a tight two-legger or a higher-risk multi, there's real parlay construction value here. Let's break down each fixture, flag the generous numbers, and hand you two to three ready-to-fire combinations.
Match-by-Match Breakdown
Atlético San Luis vs Santos Laguna – 02:00 UTC
San Luis open as clear favourites at -135 (FanDuel), giving them an implied probability of roughly 57%. That's a manageable price for a home side expected to control proceedings. Santos Laguna arrive as +330 underdogs — a lofty price that only becomes interesting if you have a strong read on their attacking threat on the road. The draw sits at +310 (FanDuel), which at 24% implied probability is not outrageous for a Liga MX fixture that could easily be tight. San Luis -135 looks like the anchor leg of any conservative parlay.
Atlas vs Tigres – 02:00 UTC
Tigres are installed as favourites here at -120 (FanDuel) — essentially a coin flip price for a side that typically carries significant quality. Atlas are live underdogs at +340, a price that bakes in a genuine upset premium. If you believe in Tigres on the road, -120 offers reasonable value as a middle-tier parlay leg without destroying your combined odds. The draw at +260 (implied ~28%) is worth noting — Atlas vs Tigres matches can be cagey, but we'd rather ride Tigres at the current number.
Mazatlán FC vs Toluca – 02:00 UTC
This is the sharpest line on the board. Toluca are -250 (FanDuel) favourites — that's a 71% implied win probability, which is a heavy chalk price. Mazatlán at +650 is massive, and the draw at +410 is the most generous draw price on the Thursday slate. At +410, the draw carries an implied probability of only about 20%, yet Liga MX home sides regularly find ways to grind out stalemates against superior opposition. Value flag: the +410 draw here looks generous if Mazatlán sit deep and frustrate Toluca — it's a speculative sprinkle bet on its own or a spicy parlay addition. For safer construction, Toluca -250 is too short to include in a multi — avoid it as a parlay leg.
Necaxa vs Guadalajara – 04:05 UTC
Guadalajara (Chivas) come in as -141 (FanDuel) favourites on the road — a moderately confident lean from the market. Necaxa at +390 is a big number for a home side. The draw at +310 mirrors the San Luis-Santos line, again reflecting a realistic chance of a stalemate. Chivas at -141 carries about 59% implied probability. That's a workable road favourite price and one of the cleaner legs to include in a parlay if you trust Guadalajara's quality to see this out.
Tijuana vs Pachuca – 04:06 UTC
This is the most open match of the night. Pachuca are slight favourites at +145 (FanDuel) — that's actually an underdog-style price despite being listed as the favourite — while Tijuana sit at +175 and the draw at +260. Value flag: Tijuana at +175 looks generous for a home side in what the market considers nearly a pick'em. The spread between the two sides is tight, but getting a home team at +175 in a near-coinflip fixture represents real value. Pachuca +145 is also an attractive price if you back them, turning a favourite into a plus-money return.
Recommended Parlay Combinations
Parlay 1 – The Confident Two-Legger (Lower Risk)
- San Luis to Win (-135, FanDuel)
- Guadalajara to Win (-141, FanDuel)
Combined odds: approximately +118 to +125 depending on parlay calculation. Two road-and-home favourites at moderate prices combining for a plus-money return. This is the bread-and-butter play for disciplined bettors who want a realistic shot at profit without chasing huge numbers. Both teams are priced as genuine favourites and the combined implied probability sits in a range where the parlay return justifies the stake.
Parlay 2 – The Value Hunter Three-Legger
- San Luis to Win (-135, FanDuel)
- Tigres to Win (-120, FanDuel)
- Tijuana to Win (+175, FanDuel)
Combined odds: approximately +350 to +380. This combination layers two reasonable road favourites with Tijuana's generous home price. The Tijuana leg at +175 is the key value driver — if the market is close to a pick'em, getting the home side at that price in a multi is where the edge lives. A $20 stake returns around $90-$96 profit if all three land.
Parlay 3 – The Speculative Swing (High Risk / High Reward)
- Guadalajara to Win (-141, FanDuel)
- Pachuca to Win (+145, FanDuel)
- Mazatlán vs Toluca Draw (+410, FanDuel)
Combined odds: approximately +900 to +1000. This is the moonshot. Chivas winning on the road anchors it, Pachuca grabbing a result at plus money adds juice, and the +410 draw in Mazatlán provides the big multiplier. The draw angle in that match is legitimately underpriced in our view — +410 on a home-side-parking-the-bus scenario is where the bookmaker may have left something on the table. Keep stakes small on this one.
Key Value Recap
- Tijuana +175 (FanDuel) — home side in a near pick'em, generous price
- Mazatlán vs Toluca Draw +410 (FanDuel) — market implied probability feels too low for a motivated home side
- Pachuca +145 (FanDuel) — favourite at plus money is always worth a look in any accumulator
Thursday's Liga MX slate gives bettors plenty of angles — from safe anchors to high-ceiling swings. Build smart, size sensibly, and good luck on the night.
Gambling should always be entertaining — bet only what you can afford to lose and use responsible gambling tools if you ever feel your betting is getting out of hand.
