A full Monday Major League Baseball slate brings 12 games and some tasty parlay opportunities. Here are the best combinations to target tonight.
Monday's Best Major League Baseball Parlay Picks - May 4, 2026
It's a loaded Monday night on the Major League Baseball schedule with 12 games spanning from the East Coast to the West Coast. With first pitches running from 6:41 PM ET all the way past 10:45 PM ET, there's plenty of time to lock in your parlays and watch the money roll in. Let's break down the best combinations tonight.
Key Matchups and Value Spots
New York Mets -1.5 (+105) vs Colorado Rockies - BetMGM
The Rockies continue to be one of the worst teams in the majors, and the Mets are a legitimate postseason contender with real pitching depth. Getting the Mets at +105 on the -1.5 run line via BetMGM is genuinely generous odds for a team of their caliber against Colorado. Coors Field can be unpredictable, but the Mets' roster quality should shine through here. This is a value leg - you're effectively getting plus-money on a favourite covering a small spread.
Philadelphia Phillies -1.5 (+143) vs Miami Marlins - Caesars
This is the standout value play of the entire slate. The Phillies are one of the premier offences in the National League, and the Marlins have struggled to win games consistently this season. Getting Philadelphia at +143 on the -1.5 run line at Caesars is exceptional value - that's a team widely regarded as a playoff calibre club at plus-money on a spread. The Phillies have the lineup depth to win by multiple runs against a depleted Miami pitching staff. This leg alone is worth building a parlay around.
Los Angeles Dodgers -1.5 (-125) vs Houston Astros - Fanatics
The Dodgers are the standard bearer in the National League and a team that regularly wins games convincingly. Houston has been inconsistent this season and facing one of the most talented rosters in baseball. At -125 on the run line, the Dodgers are a reasonably priced favourite and give your parlay a solid anchor leg. Their rotation and bullpen depth make covering -1.5 a realistic proposition even on the road.
Detroit Tigers ML (-227) vs Boston Red Sox - Fanatics
Detroit at home as a heavy favourite is a tough sell in a parlay due to the juice, but the Tigers' strong home record and the Red Sox's road struggles make the moneyline worth noting as a standalone value play. We'll leave this one out of our main parlays given the price, but it's worth tracking as a single.
Under 8.5 (+102) - New York Yankees vs Baltimore Orioles - theScore Bet
Getting over-even money on an under in what should be a tightly contested pitching-driven game at Yankee Stadium is notable. Both the Yankees and Orioles have been relying on their pitching this season, and +102 on the under 8.5 at theScore Bet gives you a plus-money line on what should be a low-scoring affair. Flag this as a genuine value spot.
Under 7.5 (+100) - Atlanta Braves vs Seattle Mariners - FanDuel
The Mariners are known for their pitching-first identity under their current roster construction, and this total sitting at 7.5 with even money on the under via FanDuel is worth targeting. Both squads lean on strong starting pitching, and late West Coast games at T-Mobile Park tend to play low.
Recommended Parlay Combinations
Parlay 1 - The Value Run Line Triple (+407 combined)
- New York Mets -1.5 (+105) - BetMGM
- Philadelphia Phillies -1.5 (+143) - Caesars
- Los Angeles Dodgers -1.5 (-125) - Fanatics
This three-legger combines three National League favourites at various run line prices. The Phillies leg at +143 is genuinely generous and drives up the combined odds significantly. All three teams are facing inferior opponents tonight, and run line parlays like this - where you're getting plus-money on individual legs - represent excellent parlay construction. Combined price lands around +407.
Parlay 2 - Underdog Totals Double (+203 combined)
- Under 8.5 (+102) - Baltimore Orioles @ New York Yankees - theScore Bet
- Under 7.5 (+100) - Atlanta Braves @ Seattle Mariners - FanDuel
Two even-money-or-better under plays from pitching-heavy matchups. The Yankees-Orioles game has all the hallmarks of a grinding, low-run contest, and the Mariners at home against Atlanta should stay tight. Combining two plus-money unders gives you a clean two-legger at around +203 - easy to tail as a small-stakes play.
Parlay 3 - The Power Combo (+541 combined)
- Philadelphia Phillies -1.5 (+143) - Caesars
- New York Mets -1.5 (+105) - BetMGM
- Under 8.5 (+102) - Baltimore Orioles @ New York Yankees - theScore Bet
The biggest parlay on the card tonight. Two plus-money run lines anchored by the Phillies' exceptional +143 spread price, combined with the over-even Yankees-Orioles under. If you believe in the Phillies' edge over Miami and trust the Mets to handle Colorado, this three-leg combo at approximately +541 offers real upside. It's a $10 bet to win $54 - the kind of value that makes Monday night baseball worth watching.
Tonight's Best Value Flag
The standout value flag tonight is the Philadelphia Phillies -1.5 at +143 (Caesars). A team of the Phillies' calibre at plus-money on a run line against one of the weakest rosters in the National League is the kind of mispricing that sharp bettors target. Make sure you're shopping Caesars for this line before it moves.
