Six Copa Sudamericana knockout ties hit the board Tuesday and Wednesday. Here are the best parlay combinations with value odds across DraftKings.
Copa Sudamericana Parlay Picks - Tuesday & Wednesday May 5-6
The CONMEBOL Copa Sudamericana rolls on with six knockout stage fixtures across Tuesday night and Wednesday, and the odds board on DraftKings is loaded with genuine value. From a wide-open three-way split in Pereira to Santos being installed as heavy favourites against a Recoleta FC side making their mark on the continental stage, there is plenty to dissect. Let's break down the best legs and build out two strong parlay combinations.
Match-by-Match Analysis
Club Independiente Petrolero vs Caracas FC - Tue 05 May 23:00 UTC
Caracas FC head to Bolivia as the market favourite at +205 on DraftKings, while the home side Petrolero are priced at +125. Playing at high altitude in Bolivia is a massive factor - Petrolero's home ground in Cochabamba sits at over 2,500 metres above sea level, and that has historically been a leveller or even an advantage for Bolivian clubs in South American competition. The draw at +225 reflects genuine uncertainty here. Petrolero at +125 to win at home represents fair value given the altitude edge, and this is a leg worth anchoring a parlay around.
CA Juventud vs Clube Atlético Mineiro - Tue 05 May 23:00 UTC
Atlético Mineiro, one of Brazil's powerhouse clubs, are narrow favourites at +115 to win away for CA Juventud. The home side sitting at +225 and the draw at +235 tells you the market respects Atlético Mineiro's quality considerably. As a Brazilian giant competing in the Copa Sudamericana rather than the Copa Libertadores this season, Mineiro will treat this competition seriously. The away win at +115 is slim value, but in a two-leg knockout tie context, Mineiro getting a result on the road is a credible outcome worth including.
Deportivo Pereira vs Grêmio - Tue 05 May 23:00 UTC
This is the most intriguing fixture on the slate. The market has essentially called a three-way coin flip - Pereira at +175, the draw at +175, and Grêmio at +185. When bookmakers price all three outcomes this close together, it signals genuine uncertainty. Grêmio at +185 as an away underdog is arguably the most appealing value here - Brazilian Serie A sides typically carry quality into South American competition and +185 is a generous price for a club of their stature. This is flagged as a value bet.
Puerto Cabello vs Club Cienciano - Wed 06 May 01:30 UTC
Puerto Cabello are favoured at home at +100 (essentially a coin flip moneyline), with Cienciano priced at +265 as the away side and the draw at +235. Puerto Cabello at even money to win at home is reasonable, and this is a game where backing the home side to get the job done offers solid parlay fodder without taking on excessive risk for minimal return.
Recoleta FC vs Santos - Wed 06 May 01:30 UTC
Santos are the standout heavy favourites of the entire slate at -204 on DraftKings. Recoleta at +550 to win and the draw at +300 underlines just how lopsided this one looks. Santos, the historic Brazilian club working their way back up through the divisions, are expected to be far too strong for Recoleta FC. At -204, Santos alone won't move the needle in a parlay, but combined with other legs they help anchor a safer combination. Note that this is a significant price to lay as a single leg, so use it wisely within a multi-leg build.
C.D. Cuenca vs San Lorenzo - Wed 06 May 03:00 UTC
The final match of the window sees Ecuadorian side Cuenca hosting Argentina's San Lorenzo. Cuenca at +145 to win at home is a tasty price - home advantage in Ecuador and the travel demands on San Lorenzo make this competitive. San Lorenzo at +180 away is slightly more generous than you might expect for an Argentine top-flight club, making it another value flag. The draw at +220 is available but this feels like a game that produces a result rather than a stalemate.
Recommended Parlay Combinations
Parlay 1 - The Value Hunter (3 legs)
- Grêmio to win vs Deportivo Pereira - Away Win at +185 (DraftKings)
- Atlético Mineiro to win vs CA Juventud - Away Win at +115 (DraftKings)
- Santos to win vs Recoleta FC - Away Win at -204 (DraftKings)
Two Brazilian giants doing what Brazilian giants do on the road in South American competition, with Santos anchoring as the near-certainty leg. The Grêmio +185 is the value driver here. Combined odds: approximately +506.
Parlay 2 - The Home Comforts Double (2 legs)
- Club Independiente Petrolero to win at home vs Caracas FC - Home Win at +125 (DraftKings)
- Puerto Cabello to win at home vs Club Cienciano - Home Win at +100 (DraftKings)
Both home sides get the nod here. Petrolero's altitude advantage over Caracas FC is a legitimate edge in South American competition, while Puerto Cabello at even money at home is fair value. Two home sides in knockout ties - straightforward and solid. Combined odds: approximately +349.
Parlay 3 - The Longshot Swing (3 legs)
- Grêmio to win vs Deportivo Pereira - Away Win at +185 (DraftKings)
- C.D. Cuenca to win at home vs San Lorenzo - Home Win at +145 (DraftKings)
- Club Independiente Petrolero to win at home vs Caracas FC - Home Win at +125 (DraftKings)
Three home-and-away upsets that the market respects as live possibilities. Grêmio at +185 remains the standout value leg. Cuenca at +145 at home against San Lorenzo provides the second punch, and Petrolero at +125 rounds it off. If all three land, the payout is significant. Combined odds: approximately +893.
Best Value Flags
- Grêmio +185 (DraftKings) - Generous price for a Brazilian Serie A club on the road in a two-leg knockout tie.
- C.D. Cuenca +145 (DraftKings) - Home advantage in Ecuador is real, and San Lorenzo's travel from Argentina is a factor the market may be underweighting.
- Petrolero +125 (DraftKings) - High-altitude home advantage is one of the most consistent edges in South American club football.
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