Bournemouth arrive as the league's form team, Arsenal travel to Brighton, and Manchester City host Sunderland at the Etihad. Full Gameweek 5 predicted lineups, kickoff times in ET, and the latest injury news for every match.
Premier League Gameweek 5 Preview: Lineups, Team News & Fixtures
Gameweek 5 has real weight behind it. Bournemouth arrive as the form team of the league, genuinely top of the pile and unbeaten so far this season, while Arsenal look to keep pace away at Brighton and Manchester City try to build momentum at home against a resilient Sunderland side. Here's the breakdown for September 18-20, with kickoff times in US Eastern.
Brentford vs Chelsea - Friday, 3:00 PM ET
Predicted Lineup Gameweek 5
- Brentford: Kelleher; Lewis-Potter, Schuster, Ajer, Kayode; Sangare, Janelt; Yarmolyuk, Anthony, Mbeumo; Thiago
- Chelsea: Martinez; Fofana, Lacroix, Acheampong; James, Caicedo, Fernandez, Gusto; Palmer, Rogers; Joao Pedro
Brentford are dealing with a genuinely long injury list heading into this one, with Nathan Collins, Mikkel Damsgaard, and Sepp van den Berg all sidelined, which thins their options at the back significantly. Chelsea have their own fitness questions, with Moises Caicedo, Facundo Emegha, Josh Henderson, and Mattia Palestra all carrying doubts, though positive news has emerged on Levi Colwill and Joao Pedro, both back in training after the win over Spurs in midweek.
Tottenham vs Aston Villa - Saturday, 7:30 AM ET
Predicted Lineup Gameweek 5
- Tottenham: Kinsky; van Hecke, van de Ven, Senesi; Robertson, Bentancur, Tonali; Marmoush, Fernandes, Savio; Solanke
- Aston Villa: Suzuki; Cash, Mings, Lindelof, Maatsen; Kamara, Barkley; Buendia, McGinn, Hemmings; Jackson
Spurs have a genuine team news cloud around this one, with Sandro Tonali a doubt and both Destiny Udogie and Dejan Kulusevski also flagged, on top of Mudryk and Odobert already ruled out entirely. Villa travel to London full of confidence after a strong run of form, with Nicolas Jackson continuing to lead the line following his move from Chelsea in the summer.
Brighton vs Arsenal - Saturday, 10:00 AM ET
Predicted Lineup Gameweek 5
- Brighton: Verbruggen; Boscagli, Dunk, Vuskovic; Wieffer, Ayari, Gross; De Cuyper, Hinshelwood, Gomez; Rutter
- Arsenal: Raya; White, Gabriel, Calafiori, Konsa; Lewis-Skelly, Rice, Odegaard; Saka, Havertz, Tzolis
William Saliba remains out long-term for Arsenal, while Jurrien Timber and Ricardo Mosquera are both rated as roughly 75 percent fitness doubts, a genuine squad-depth test for Mikel Arteta at the back. Ben White reportedly looked to be carrying a knock after Arsenal's midweek cup win but has since been cleared as fit to feature. Brighton's model of developing and reselling talent keeps producing a competitive squad regardless of who's actually on the team sheet.
Everton vs Ipswich Town - Saturday, 10:00 AM ET
Predicted Lineup Gameweek 5
- Everton: Pickford; Patterson, Tarkowski, Branthwaite, Mykolenko; Gueye, Garner; Dewsbury-Hall, Armstrong, George; Barry
- Ipswich Town: Scherpen; Davis, Diop, Greaves; O'Shea, Palacios, Lukic; Maeda, Enciso, Fatawu; Emersonn
Everton head into this one as one of the more favorable fixtures on this weekend's slate, and a home date against a struggling Ipswich side is exactly the kind of match they'll want to turn into three points. Ipswich continue their battle to establish any real foothold in the league this season.
Leeds vs Crystal Palace - Saturday, 10:00 AM ET
Predicted Lineup Gameweek 5
- Leeds: Trafford; Ampadu, Bijol, Muharemovic; Justin, Stach, Gudmundsson, Bogle; Wilson, Aaronson; Calvert-Lewin
- Crystal Palace: Henderson; Richards, Canvot, Tomiyasu; Mitchell, Kamada, Wharton, Khalaili; Timber, Nketiah; Strand Larsen
Elland Road continues to be one of the more talked-about atmospheres in the league this season, and Leeds will need that home energy against a well-drilled Palace side. Palace's squad depth has looked strong through the opening weeks, and their front line has found real rhythm.
Newcastle vs Hull City - Saturday, 10:00 AM ET
Predicted Lineup Gameweek 5
- Newcastle: Hornicek; Livramento, Thiaw, Botman, Hall; Ramsey, Miley; Barnes, Fernandez-Pardo, Wissa; Osula
- Hull City: Tzolakis; Coyle, Egan, Mendy, Giles; Slater, Gourna-Douath; Belloumi, Stroud, Morita; McBurnie
Newcastle are dealing with a fresh setback, having lost Anthony Elanga to injury, which changes the shape of their attacking options. This is genuinely one of the more favorable home matchups of the gameweek for a Newcastle side looking to build early-season momentum, with newly-arrived Matias Fernandez-Pardo continuing to settle into a regular starting role.
Nottingham Forest vs Coventry City - Saturday, 12:30 PM ET
Predicted Lineup Gameweek 5
- Nottingham Forest: Sels; Milenkovic, Murillo, Cunha; Williams, Sangare, Gibbs-White, Aina; Schlager, Ndoye; Igor Jesus
- Coventry City: Rushworth; Dasilva, Thomas, Amenda, van Ewijk; Yirenkyi, Grimes; Hamer, Rudoni, Tchaouna; Awoniyi
Forest are another side with a strong home matchup this week, and their manager will be looking to build on recent form against a Coventry side still finding its feet in the top flight after promotion.
Manchester City vs Sunderland - Sunday, 9:00 AM ET
Predicted Lineup Gameweek 5
- Manchester City: Donnarumma; Gvardiol, Guehi, Dias, Nunes; Rodri, O'Reilly; Semenyo, Cherki, Foden; Haaland
- Sunderland: Roefs; Hume, Mukiele, Alderete, Cirkin; Xhaka, Sadiki; Angulo, Le Fee; Danso; Brobbey
City return home to the Etihad off the back of a midweek cup win, looking to build momentum after a bumpy start to the title race. Sunderland's mid-block structure, built around Granit Xhaka, Kevin Danso, and Daniel Ballard, will look to frustrate City's central passing lanes while springing Brian Brobbey on the counter, a plan that's earned Sunderland real respect already this season despite their newly-promoted status.
Bournemouth vs Liverpool - Sunday, 9:00 AM ET
Predicted Lineup Gameweek 5
- Bournemouth: Petrovic; Smith, Hill, Silva, Truffert; Scott, Adams; Kluivert, Rayan, Tavernier; Evanilson
- Liverpool: Alisson; Frimpong, Jacquet, Van Dijk, Araujo; Mac Allister, Gravenberch; Szoboszlai, Wirtz, Gakpo; Isak
This is arguably the standout fixture of the weekend for neutral fans. Bournemouth are genuinely the form team of the Premier League right now, and their unbeaten run is a real story worth following as the season develops. Liverpool carry a fitness question over Cole Gakpo, who's dealing with a thigh issue, rated as roughly a 75 percent chance to play, a flag worth watching given how central he's been to their attack.
Fulham vs Manchester United - Sunday, 11:30 AM ET
Predicted Lineup Gameweek 5
- Fulham: Leno; Robinson, Andersen, Bassey, Castagne; Iwobi, Berge; Palacios, King, Bobb; Garcia
- Manchester United: Lammens; Mazraoui, Maguire, Martinez, Shaw; Mainoo, Tielemans; Mbeumo, Fernandes, Rashford; Cunha
Fulham's defensive setup under Marco Silva continues to be one of the most underrated in the league, and they'll fancy their chances of frustrating a United side still finding its rhythm under Michael Carrick. United will look to carry momentum from a strong derby atmosphere into a fixture that's historically been trickier for them than the table position suggests it should be.
These predicted lineups draw on the most current team news and fitness reports available as of a few days before kickoff, but they are not official confirmed team sheets. Confirmed lineups won't be locked in until roughly an hour before each match, so check back closer to kickoff for anything that changes, particularly around the fitness doubts flagged for Arsenal, Tottenham, and Chelsea.
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