Three NBA games on Wednesday April 22 offer some tasty parlay angles. Here are the best combinations and value spots from tonight's slate.
NBA Parlay Picks - Wednesday April 22, 2026
Three NBA matchups light up the Wednesday slate and the odds board is giving us some clear angles to work with. From a heavy Boston favourite at home to a genuinely intriguing Lakers-Rockets showdown, there is enough meat on the bone to build some strong parlay combinations. Let us break it all down.
Game-by-Game Breakdown
Philadelphia 76ers @ Boston Celtics (-833 FanDuel, 00:10 UTC)
Boston is an absolute monster favourite here at -833 on FanDuel, implying roughly a 89% win probability. That kind of price makes the Celtics useless as a standalone bet - you are risking nearly nine dollars to win one. However, as a parlay anchor leg, Boston covering at home against a Philadelphia side that has struggled for consistency all season is a reasonable foundation. The Celtics have been one of the elite home teams in the NBA and their defensive identity makes them tough to beat on their own floor.
Philadelphia at +700 on FanDuel is a massive number - that implies just a 12.5% win probability. Unless the 76ers are dramatically healthier than expected and Boston is resting key players, this is a fade situation. We are not recommending a 76ers straight-up bet here.
Portland Trail Blazers @ San Antonio Spurs (-625 FanDuel, 01:00 UTC)
San Antonio at -625 on FanDuel implies around an 86% win probability. The Spurs have been one of the more reliable home teams when it comes to protecting their floor against lower-tier opponents, and Portland has been firmly in rebuilding mode. The Trail Blazers are not expected to be competitive with the league's rising young teams, and San Antonio - led by Victor Wembanyama - has the talent to make this a comfortable home win.
Portland at +510 on FanDuel is tempting on paper for a speculative dart, but without confirmed form data backing a Blazers resurgence, chasing that number is a low-percentage play.
Houston Rockets @ Los Angeles Lakers (+160 FanDuel, 03:40 UTC)
This is the most interesting game on the slate. Houston at -175 on FanDuel implies roughly a 63.6% win probability, which feels like a reasonable reflection of the Rockets' strength as a young, physical, defensive-minded squad. Los Angeles at +160 on FanDuel implies just a 38.5% win probability - and this is where the value flag goes up.
The Lakers at +160 represents a genuine value opportunity. A gap between implied probability and true probability exists when a famous, deep franchise plays at home against a team that, despite being good, has to travel to one of the toughest road environments in the league. If the Lakers have anything to play for - playoff seeding, home-court positioning - this number looks generous. +160 on the Lakers is our top standalone value bet of the night.
Recommended Parlay Combinations
Parlay 1 - The Safe Double (Two Legs)
- Boston Celtics ML (-833, FanDuel)
- San Antonio Spurs ML (-625, FanDuel)
Combined odds: approximately -145. This is a low-risk, modest-return parlay built on two heavy home favourites. You are combining two teams with implied win probabilities above 85%. The combined true probability sits around 77%, giving you a reasonable expected value if both sides are as dominant as their prices suggest. Best for bettors who want a near-lock double without leaving too much on the table.
Parlay 2 - The Value Double (Two Legs)
- Houston Rockets ML (-175, FanDuel)
- Boston Celtics ML (-833, FanDuel)
Combined odds: approximately +120. You are pairing the safest anchor on the board with the Rockets, who are legitimate favourites in a game where they hold a structural edge. Getting plus-money on this combination makes it excellent risk-reward. If you believe in Houston's system and Boston's dominance, this is the parlay to play.
Parlay 3 - The Value Hunter Triple (Three Legs)
- Boston Celtics ML (-833, FanDuel)
- San Antonio Spurs ML (-625, FanDuel)
- Los Angeles Lakers ML (+160, FanDuel)
Combined odds: approximately +195. This is the most aggressive combination on the card. You are layering two near-locks with the Lakers as a live underdog at home. If the Lakers show up motivated and the Rockets travel tired after a tough stretch, +195 on this parlay is genuinely appealing. This is the highest-ceiling option on the slate and the one to target if you believe in the Lakers value.
Top Value Flag
Los Angeles Lakers +160 (FanDuel) - The implied probability of 38.5% feels too low for a Lakers home game. Market inefficiency on high-profile franchises playing at home is well-documented, and this number stands out as the most generous price on the Wednesday slate. Even a small unit on the Lakers straight up has merit alongside any parlay combination.
Betting Summary
- Best Anchor Leg: Boston Celtics ML (-833, FanDuel)
- Best Value Bet: Los Angeles Lakers ML (+160, FanDuel)
- Best Overall Parlay: Celtics + Rockets - approximately +120 combined
- Best Value Parlay: Celtics + Spurs + Lakers - approximately +195 combined
Wednesday's NBA slate is compact but packed with opportunity. Anchor your parlays with the Boston and San Antonio locks, then decide how much Lakers faith you are willing to stake. The +160 on Los Angeles is the number that deserves your attention tonight.
Please gamble responsibly - set a budget before you bet and never wager more than you can afford to lose.
