Six Copa Sudamericana knockout ties hit the card Wednesday and Thursday. Here are the best parlay combinations with top odds from DraftKings.
Copa Sudamericana Parlay Picks - Wednesday May 20 & Thursday May 21
The CONMEBOL Copa Sudamericana knockout stage rolls on this week with six compelling fixtures spread across Wednesday evening and Thursday morning UTC. The markets are live, the lines are set, and there are some genuinely interesting value spots hiding in plain sight. Let's break down the best parlay combinations available right now on DraftKings.
Match-by-Match Analysis
Olimpia Asunción vs Vasco da Gama (Wed 20 May, 23:00 UTC)
Olimpia Asunción are priced as slight favourites at +140 with DraftKings, which feels about right for a Paraguayan side playing at home in Asunción. Vasco da Gama come in as narrow underdogs at +195, and with the draw available at +215, this is one of the most evenly contested fixtures on the slate. Knockout football at this stage tends to be tight and cagey - teams respect the two-legged format and often set up defensively in the first leg. The draw at +215 represents genuine value here given the closely matched pricing across all three outcomes. That implied probability of roughly 32% looks low for what is a dead-even contest on paper.
Santos vs San Lorenzo (Wed 20 May, 23:00 UTC)
Santos are installed as home favourites at -130 on DraftKings, which reflects the Vila Belmiro atmosphere and the Brazilian club's structural advantages in terms of squad depth. San Lorenzo are a large price at +350 for the away win, while the draw sits at a chunky +250. Santos at -130 is not a bad price for a Brazilian side at home in South American competition, and this one fits well as a parlay anchor leg - the implied probability of around 57% seems fair without being greedy.
CA Boston River vs O'Higgins (Wed 20 May, 23:00 UTC)
This is the fixture where the market has spoken loudly. O'Higgins are priced as clear favourites at -110 on the road against Uruguayan side CA Boston River, who are the big underdogs at +290. O'Higgins arriving as road favourites tells you everything about the quality gap the market perceives here. The Chilean side at -110 is essentially a pick'em price on what the bookmakers clearly believe is a one-sided affair. This leg carries solid value as part of a multi.
Grêmio vs Palestino (Thu 21 May, 01:00 UTC)
Grêmio are massive favourites at -256 on DraftKings against Chilean side Palestino, who are listed as huge underdogs at +650. The draw is +350. The juice on Grêmio is heavy and building a parlay around -256 is inefficient on its own, but the implied dominance is notable context for other legs. Palestino are genuine longshots here and the market is not shy about saying so.
Club Independiente Petrolero vs Botafogo (Thu 21 May, 01:00 UTC)
Botafogo are the most lopsided favourites on the entire slate at -526 away to Club Independiente Petrolero of Bolivia. The Bolivian side at +1000 is a massive longshot and the draw sits at +550. Botafogo are the reigning Copa Libertadores champions and represent an enormous class gap versus a Bolivian outfit. While -526 is brutal to include raw in a parlay, the underlying conviction in Botafogo winning is near-certain - context worth keeping in mind.
River Plate vs Bragantino-SP (Thu 21 May, 01:30 UTC)
Note this is River Plate of Uruguay (not the Argentine giants), which explains why they are only slight favourites at -110 against Bragantino-SP, who are priced at +310 for the away win. The draw is +230. Bragantino have strong Brazilian Serie A pedigree and +310 for the Brazilian side represents outstanding value if you believe in their quality to travel and perform. This could be the value play of the night.
Recommended Parlay Combinations
Parlay 1 - The Value Treble (+802 combined, DraftKings)
- Olimpia Asunción vs Vasco da Gama - Draw (+215, DraftKings) - Even markets in knockout football heavily favour the draw, and +215 is generous for this balanced contest.
- Santos to beat San Lorenzo (-130, DraftKings) - Brazilian side at home is a solid anchor at a fair price.
- O'Higgins to beat CA Boston River (-110, DraftKings) - Road favourites at near pick'em odds is excellent value in a Copa Sudamericana knockout tie.
Combined odds: approximately +802. Three legs, logical reasoning on each, and the draw pick at +215 acts as the value kicker that inflates the combined price nicely.
Parlay 2 - The Brazilian Double (+560 combined, DraftKings)
- Santos to beat San Lorenzo (-130, DraftKings) - Home advantage and Brazilian quality.
- Bragantino-SP to beat River Plate (+310, DraftKings) - This is the value flag of the night. Bragantino at +310 away in what should be a competitive tie is extremely generous. The implied probability of roughly 24% underestimates a strong Brazilian side significantly.
Combined odds: approximately +560. A two-legger with a genuine value underdog injected in - Bragantino at +310 is the pick to circle. If you believe in Brazilian football quality in CONMEBOL competition, this combination delivers outstanding potential return for just two legs.
Parlay 3 - The Favourites Treble (+208 combined, DraftKings)
- Santos to beat San Lorenzo (-130, DraftKings)
- O'Higgins to beat CA Boston River (-110, DraftKings)
- River Plate (Uruguay) vs Bragantino-SP - Draw (+230, DraftKings) - If you are not ready to back Bragantino outright, the draw at +230 in what is a genuinely even fixture is a solid hedge position that still pays well in the parlay.
Combined odds: approximately +208. This is the lower-risk, lower-reward option - a solid parlay for those who want a more conservative approach with three defensible picks.
Value Flags to Watch
- Bragantino-SP +310 (DraftKings) - Best value on the slate. A Brazilian top-flight club at +310 to win a single-leg Copa Sudamericana match looks mispriced.
- Olimpia vs Vasco Draw +215 (DraftKings) - When three outcomes are priced this closely, the draw is almost always undervalued due to bettor bias toward backing a winner.
- O'Higgins -110 away (DraftKings) - Being a road favourite at -110 in South American knockout football is significant and the market is telling you the quality gap is real.
All odds are from DraftKings and subject to change. Always verify current lines before placing any bets.
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