A loaded 12-game Major League Soccer weekend slate offers prime parlay value. Here are our top combinations with the best available odds.
Major League Soccer Weekend Parlay Picks - May 23-24, 2026
A massive 12-game Major League Soccer slate runs across Saturday and Sunday, giving us plenty of angles to build some sharp parlay combinations. We've combed through the live market data to identify the best prices, spot genuine value, and piece together three recommended parlays ranging from safe-ish two-leggers to a bigger-odds multi.
Let's get into it.
Game-by-Game Breakdown
St. Louis City SC vs Austin FC (Sat 23 May, 19:45 UTC)
St. Louis open as solid home favourites at -145 (BetMGM), and the market is telling us to expect goals - BTTS YES is a short -167 at FanDuel. The total sits at 2.5 with the over priced at -164, suggesting bookmakers expect a relatively free-flowing game. We're not interested in laying heavy juice on the over here, but St. Louis at home to a travelling Austin side looks a sensible favourite play.
Minnesota United FC vs Real Salt Lake (Sat 23 May, 21:30 UTC)
This is one of the more open lines on the board. Minnesota come in at a modest +125 (Bally Bet) on the home side - that's effectively a coin-flip game with upside on the home team. The over 3.5 at +138 (Bally Bet) is interesting value if you believe both sides can trade goals. BTTS YES is a very short -189 at BetMGM, underlining the expectation of a high-scoring affair.
Charlotte FC vs New England Revolution (Sun 24 May, 00:30 UTC)
Charlotte open as slim home favourites at -105 (Bally Bet) against a New England side priced at +300 (Caesars) - a big gap that reflects the Revolution's struggles on the road. Charlotte covering at home looks attractive. The total is set at 2.5 with the over at -145 (BetMGM), so the market leans toward a scoring game but isn't overwhelming.
FC Cincinnati vs Orlando City SC (Sun 24 May, 00:30 UTC)
FC Cincinnati are heavy home favourites at -164 (BetMGM), and BTTS NO is a standout price at +215 (DraftKings) - implying roughly a 32% chance that one side gets shut out, which feels generous if Cincinnati are as dominant at home as that price implies. That's our value flag of the slate. The over 3.5 at -127 also suggests the market expects Cincinnati to pile on.
D.C. United vs CF Montreal (Sun 24 May, 00:30 UTC)
D.C. United are slight home favourites at -110 (BetMGM) in what looks like a balanced contest. The total is tight around 2.5, with the under at +102 (Bally Bet) offering a near-even money return on a low-scoring outcome. Montreal at +290 (FanDuel) away is a long shot but not impossible.
Nashville SC vs New York City FC (Sun 24 May, 01:30 UTC)
Nashville are backed at -130 (theScore Bet) to win at home and this feels like a sensible favourite play. NYFC away at +360 (Bally Bet) is a big price. The total sits at 2.5 with the under at +105 (Bally Bet), which is near-even value on a potentially cagey mid-table clash.
Chicago Fire vs Toronto FC (Sun 24 May, 01:30 UTC)
Chicago are massive home favourites at -200 (BetMGM) against a Toronto side priced at a whopping +525 (Caesars). Toronto's away record must be dire to justify that price. The under 3.5 at -154 (Bally Bet) suggests this might be a grind rather than a goal fest despite the one-sided nature of the match-up.
Sporting Kansas City vs New York Red Bulls (Sun 24 May, 01:30 UTC)
This is a fascinating line - Sporting Kansas City are priced at +220 (Caesars) at home while New York Red Bulls come in as a modest favourite alternative at +110 (Bally Bet). BTTS YES is a short -270 (DraftKings), making it clear the market expects both sides to find the net. The over 3.5 at +100 (Bally Bet) is even money and worth a look as a standalone value play.
San Diego FC vs Vancouver Whitecaps FC (Sun 24 May, 02:30 UTC)
Vancouver are slight away favourites at -102 (BetMGM), essentially a pick'em game. BTTS NO at +184 (FanDuel) is an interesting angle if you think this stays tight and one side keeps a clean sheet. The under 3.5 at -143 (Bally Bet) is the market lean.
Colorado Rapids vs FC Dallas (Sun 24 May, 02:30 UTC)
A genuinely open three-way with Colorado at +125 (Caesars), FC Dallas at +200 (Fanatics), and the draw at +280 (Fanatics). BTTS NO at +160 (FanDuel) is another price worth noting in a game where neither side looks particularly clinical.
Portland Timbers vs San Jose Earthquakes (Sun 24 May, 02:30 UTC)
Portland at +150 (Caesars) as home favourites is a solid price, making them a candidate for parlay inclusion. The over 3.5 at +106 (Bally Bet) is near-even money value. BTTS YES is a short -263 (theScore Bet), so expect both sides to score.
LA Galaxy vs Houston Dynamo (Sun 24 May, 03:30 UTC)
LA Galaxy open at +100 (Caesars) - even money at home - against a Houston side at +250 (Bally Bet). The under 2.5 at +132 (Bally Bet) is the best price on this game and represents real value for a potentially defensive late-night clash on the West Coast.
Value Flag: FC Cincinnati BTTS NO at +215
When a team is -164 to win at home, there's a legitimate case that they keep a clean sheet. DraftKings pricing BTTS NO at +215 implies only a 32% chance of that outcome - we think it's higher. This is the standout value price on the entire slate and worth including as a standalone or within a parlay.
Recommended Parlay Combinations
Parlay 1 - The Weekend Value Double (+326)
A two-leg combination targeting genuine favourites at digestible odds:
- Charlotte FC to win (Home) vs New England Revolution - -105 (Bally Bet)
- Nashville SC to win (Home) vs New York City FC - -130 (theScore Bet)
Both sides are home favourites in games where the away teams are massively priced. Charlotte at -105 is practically a pick'em but the value over New England at +300 is clear. Nashville at -130 at home is a straightforward play. Combined odds: approximately +326.
Parlay 2 - The Goals Accumulator (+388)
Three legs targeting over/under and BTTS markets across different fixtures:
- Minnesota United FC vs Real Salt Lake - Over 3.5 goals - +138 (Bally Bet)
- FC Cincinnati vs Orlando City SC - BTTS NO - +215 (DraftKings) - our value flag
- LA Galaxy vs Houston Dynamo - Under 2.5 goals - +132 (Bally Bet)
The Minnesota game screams goals with BTTS YES at -189 and an open three-way line. FC Cincinnati's dominance at home makes BTTS NO at +215 a genuine value angle. And the late Galaxy-Dynamo fixture leans defensive with the under at a generous +132. Combined odds: approximately +388.
Parlay 3 - The Upset Special (+734)
A higher-risk, higher-reward three-leg parlay mixing a value underdog, a home win, and a totals leg:
- Portland Timbers to win (Home) vs San Jose Earthquakes - +150 (Caesars)
- St. Louis City SC to win (Home) vs Austin FC - -145 (BetMGM)
- Sporting Kansas City vs New York Red Bulls - Over 3.5 goals - +100 (Bally Bet)
Portland at +150 at home is a legitimate value price for a home favourite, giving this parlay a boosted ceiling. St. Louis at -145 adds a solid anchor leg. The SKC vs Red Bulls over at even money is an ideal top-up given how strongly the market expects both teams to score in that fixture. Combined odds: approximately +734.
Best Standalone Value Pick
If you're not parlaying, the FC Cincinnati BTTS NO at +215 (DraftKings) stands out as the single best value play on Saturday's and Sunday's Major League Soccer card. A heavy home favourite containing an away side is a historically repeatable pattern, and +215 is a very generous price for that outcome.
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