A massive 13-game Memorial Day MLB slate is on tap. Here are the best parlay combinations to target on Monday, May 25.
Monday Memorial Day MLB Parlay Picks - May 25, 2026
It doesn't get much better than a 13-game Major League Baseball slate on Memorial Day. With games running from early afternoon all the way past 10 PM ET, there's plenty of value to mine across the board. We've dug into the live market odds to identify the sharpest parlay combinations for today's action. Let's get into it.
Monday MLB Betting Overview
The market data shows some interesting pricing across today's slate. A few heavy favourites stand out - the Los Angeles Dodgers are monstrous -303 moneyline chalk against the Colorado Rockies, the Milwaukee Brewers sit at -208 against the St. Louis Cardinals, and the Toronto Blue Jays are -167 at home against the Miami Marlins. Rather than leaning into those brutal prices on the moneyline, we'll focus on spreads and totals where the value actually lives on a Memorial Day card.
Key Matchups to Watch
New York Yankees @ Kansas City Royals (4:41 PM ET)
The Yankees are priced as solid road favourites at -149 moneyline, but the spread is where the value lies. New York at -1.5 fetches +110 at theScore Bet - that's a positive-money line on the run-line for a team that projects as a clear favourite. The Yankees have the offensive firepower to win by multiple runs, and Kansas City has been inconsistent at home this season. The total of 9 is the highest on today's slate, reflecting two lineups that can score, but the Yankees' pitching has been strong enough to keep this manageable.
Cleveland Guardians vs. Washington Nationals (7:11 PM ET)
Cleveland at home against Washington is a strong lean. The Guardians are -175 favourites on the moneyline, but the -1.5 spread at +125 on Bally Bet is a much more attractive play. Washington ranks among the weaker offences in the National League, and Cleveland's pitching staff at home has been excellent. The under 8 at -104 (Bally Bet) is also appealing here - this has low-scoring game written all over it.
Tampa Bay Rays @ Baltimore Orioles (2:36 PM ET)
Tampa Bay opening as -127 road favourites against Baltimore is notable. The Rays' run differential and pitching depth have made them legitimate favourites even in road spots. The -1.5 spread at +135 on Fanatics is a generous number for a team capable of controlling games from start to finish. Grabbing positive money on a team you already like to win outright is exactly the kind of edge you want to exploit in a parlay.
Toronto Blue Jays vs. Miami Marlins (8:08 PM ET)
Miami is one of the worst teams in the American League, and Toronto at home is a comfortable spot. The Blue Jays -1.5 spread at +135 on Caesars is excellent value. Laying -167 on the moneyline is painful, but +135 on the run-line essentially asks: can Toronto win by 2 or more? Given Miami's struggles, that's a highly reasonable ask. The under 7.5 at -108 (Bally Bet) is also worth a look given Miami's near-league-worst offence.
Parlay Recommendations
Parlay 1 - Memorial Day Power Spread Parlay (+452)
This three-leg spread parlay targets positive-money run-line prices on teams we trust to win comfortably.
- New York Yankees -1.5 (+110) - theScore Bet - Positive money on the Yankees run-line is a gift. They have the bats to win convincingly in Kansas City.
- Cleveland Guardians -1.5 (+125) - Bally Bet - Cleveland at home against Washington is a strong spot. The Guardians' pitching makes covering the run-line very achievable.
- Tampa Bay Rays -1.5 (+135) - Fanatics - The Rays as positive-money run-line favourites on the road is the kind of value parlay builders dream about. Back them to win by 2+.
Combined Parlay Odds: +452 - A $100 bet returns $552.
Parlay 2 - Run-Line and Under Combo (+389)
This parlay mixes a run-line favourite with two low-scoring totals targeting the under.
- Toronto Blue Jays -1.5 (+135) - Caesars - Home run-line value against one of baseball's worst offences. Toronto wins big or wins twice - either way Miami rarely hangs around.
- Cleveland Guardians / Washington Nationals Under 8 (-104) - Bally Bet - Cleveland's pitching suppresses offences at home. Washington doesn't score in bunches. This game screams 4-2 or 3-1 final.
- Tampa Bay Rays @ Baltimore Orioles Under 7.5 (+100) - BetMGM - Getting even money on an under is excellent line value. Both pitching staffs are capable of keeping this one tight and low-scoring on a Monday afternoon.
Combined Parlay Odds: +389 - A $100 bet returns $489.
Parlay 3 - Value Underdog Moneyline Parlay (+548)
For bettors who love a longer shot with genuine reasoning behind it, this two-leg underdog play targets teams with real chances at upset prices.
- Houston Astros ML (+115) - theScore Bet - The Astros getting plus money against Texas is a value flag. Houston has the pitching depth and lineup quality to win this division rivalry game, and +115 feels a touch generous for a team of their calibre.
- Arizona Diamondbacks ML (+120) - BetMGM - Arizona at +120 against San Francisco is intriguing. The D-backs have a capable rotation and lineup that can exploit a Giants side that hasn't been convincing at home. This price looks a tick too wide.
Combined Parlay Odds: +548 - A $100 bet returns $648.
Best Individual Value Bet of the Day
The standout single-game value flag today is the Tampa Bay Rays -1.5 at +135 (Fanatics). Getting a team favoured on the moneyline at a positive price on the run-line is rare, and it makes them one of the most attractive standalone plays on the entire slate. If you're only making one bet today, this is the one to consider adding to your ticket.
Please gamble responsibly - set a budget before you bet and never wager more than you can afford to lose.
