A massive 16-game Tuesday MLB slate offers plenty of parlay value. Here are our top combinations for September 22.
Tuesday's Major League Baseball Parlay Picks - September 22
A loaded 16-game Tuesday Major League Baseball slate is on the books, and with playoff races heating up across both leagues, the betting angles are sharp. We've combed through the live market odds to identify the best parlay combinations for tonight's action. Let's get into it.
Game-by-Game Analysis
New York Yankees vs. Tampa Bay Rays (14:06 ET & 20:06 ET)
The Yankees host the Rays in a doubleheader today, and both games present interesting angles. The Rays are listed as a slight underdog in the moneyline market, with Tampa Bay Rays ML at +112 (Bally Bet) in the afternoon game. The Yankees are modest favorites at -123 to -128 across books. With the Yankees playing meaningful late-season baseball at home and Tampa Bay in full rebuild mode, New York looks like solid value as the home favorite. In the evening game, the Yankees ML -128 (Courtside) offers a clean number. The totals for the second game sit at 6.5 - a low number that reflects potential bullpen matchups in a doubleheader finale.
Milwaukee Brewers @ Philadelphia Phillies (19:41 ET)
The Phillies are one of the hottest teams in the National League, pushing hard for a top seed in the postseason. Philadelphia is a -133 favorite on the moneyline, but the more interesting line is the Phillies -1.5 spread at +160 (theScore Bet). That's a generous price for a team that has the lineup and rotation depth to win convincingly at home. The Brewers have been competitive, but this spot looks tough. The total sits at 7.5 and both teams have capable offenses - Over 7.5 at +110 (theScore Bet) looks like a value play here.
Pittsburgh Pirates vs. St. Louis Cardinals (19:41 ET)
Pittsburgh are favored at home against the Cardinals, sitting at -145 on the ML. The Cardinals ML +132 (Courtside) represents real value if you believe in the upset. St. Louis has a lineup capable of putting up runs against the Pirates' staff. The Under 7.5 at -123 (FanDuel) is a bit pricey for our tastes, but the total market is telling a low-scoring story here.
Cincinnati Reds @ Atlanta Braves (20:16 ET)
Atlanta are massive -185 favorites at home, which is understandable given their lineup on paper, but that price is hard to back in a parlay. The Braves -1.5 spread at +120 (Fanatics) is a much smarter play - getting plus money on a team expected to win by multiple runs is textbook value. The Reds are essentially playing out the string at this stage of the season.
Arizona Diamondbacks @ Colorado Rockies (21:41 ET)
Coors Field is always a wildcard, but Arizona comes in as -189 moneyline favorites. The Diamondbacks -1.5 spread at -120 (FanDuel) is the sharper way to play this game, and the Over 11 at +100 (BetMGM) at Coors with two active offenses is worth a look as a standalone. Arizona should have enough firepower to cover a modest run line in the thin Denver air.
San Diego Padres @ Los Angeles Dodgers (23:11 ET)
The late-night marquee matchup. The Dodgers sit at -118 on the ML (BetMGM) - not a huge number for the best team in baseball. San Diego Padres ML +105 (BetRivers) is an intriguing underdog play given the Padres' rotation talent, but Los Angeles at home in a playoff race spot is hard to fade. The Over 8.5 at +101 (Caesars) looks like a value flag - two of the best offenses in the NL, and essentially even money on the Over.
Value Flag
The standout value alert today is Atlanta Braves -1.5 at +120 (Fanatics). Getting plus money on a run line for a team favored by nearly two runs on the moneyline implies the market is giving you a gift on the spread. This is one of the sharpest prices on the entire board today.
Recommended Parlay Combinations
Parlay 1 - The Favourites Cover Parlay (+388 combined)
- Atlanta Braves -1.5 (-120) - Fanatics - Best run-line value on the board
- Philadelphia Phillies -1.5 (+160) - theScore Bet - Phillies at home in a playoff push, Brewers on the road
- New York Yankees ML (-128) - Courtside - Yankees at home in the evening game of the doubleheader
Three strong home favorites covering or winning outright. The Phillies leg at +160 is what makes this parlay pop - that spread price is genuinely generous for a team of Philadelphia's caliber at home. Combined odds: +388.
Parlay 2 - The Value Underdog Parlay (+497 combined)
- St. Louis Cardinals ML (+132) - Courtside - Road underdog with upset upside
- Tampa Bay Rays ML (+112) - Bally Bet - Rays have historically been excellent in doubleheader spots
- San Diego Padres ML (+105) - BetRivers - Near-even money against the Dodgers, elite rotation edge
A three-leg underdog special. None of these picks are massive longshots, and stringing together three modest underdogs creates compelling combined odds. If even one of these dogs hits as a heavy favorite, the whole parlay cashes. Combined odds: +497.
Parlay 3 - Two-Leg Sharp Play (+204 combined)
- Philadelphia Phillies Over 7.5 (+110) - theScore Bet - Two capable offenses, playoff atmosphere, ball should fly
- Arizona Diamondbacks -1.5 (-120) - FanDuel - Arizona's lineup is built for Coors, cover a modest run line at a fair price
A safer two-legger for bettors who want a more conservative approach. The Phillies Over has genuine merit given both teams' offensive capabilities, and Arizona at Coors covering -1.5 is a reasonable ask. Combined odds: +204.
Best Bets Summary
- Atlanta Braves -1.5 +120 (Fanatics) - Top value pick of the day
- Philadelphia Phillies -1.5 +160 (theScore Bet) - Generous spread price for a top-tier home team
- San Diego Padres ML +105 (BetRivers) - Near-even money on a quality team with pitching edge potential
- Phillies Over 7.5 +110 (theScore Bet) - Value on the total in a marquee evening game
Always shop lines before placing - these odds are live and move quickly on a busy Tuesday slate. Good luck tonight.
Please gamble responsibly - set a budget before you bet and never wager more than you can afford to lose.
