Premier League Gameweek 6 Predicted Lineups: Liverpool vs Manchester City

Premier League Gameweek 6 Predicted Lineups: What You Need to Know

Gameweek 6 of the 2026/27 Premier League season arrives with a headline fixture that bettors will not want to miss: Liverpool host Manchester City in what shapes up as a near-even contest, with Alexander Isak listed as questionable and Phil Foden suspended for the visitors. The availability cloud hanging over both clubs adds genuine uncertainty to one of the season's most anticipated matchups so far.

Elsewhere, Arsenal welcome newly promoted Leeds United to the Emirates while carrying several doubts of their own, Manchester United host a Tottenham side missing three key contributors, and a tight Aston Villa versus Brentford meeting rounds out a Saturday slate stacked with parlay-building opportunities. Across the board, the injury list is long, so be sure to track late team news before locking in any bets.

Arsenal vs Leeds United - Saturday, 7:30 AM ET

Predicted Lineup Gameweek 6

Arsenal: Raya; Calafiori, Konsa, Gabriel, Timber; Rice, Guimaraes; Eze, Odegaard, Saka; Gyokeres
Leeds United: Trafford; Justin, Elvedi, Muharemovic; Gudmundsson, Tanaka, Ampadu, Bogle; Stach, Okafor; Calvert-Lewin

Arsenal are expected to be without William Saliba, who is listed as out, while both Declan Rice and Bruno Guimaraes carry questionable tags heading into this one. If Rice is unable to go, Arsenal's defensive midfield structure could look significantly different. Ben White is also flagged as doubtful, though Riccardo Calafiori is predicted to fill in at left back. Christos Tzolis is out for Leeds, and Mateo Joseph and Joe Rodon are also unavailable, leaving Daniel Calvert-Lewin as the lone striker and Harry Wilson as a doubt from the wing.

For bettors, Arsenal are heavy favorites at home regardless of those doubts, and the presence of Viktor Gyokeres and Bukayo Saka in attack gives the Gunners serious goalscorer appeal. A moneyline on Arsenal or a Gyokeres or Saka anytime scorer could fit neatly into a parlay. Leeds are operating with a depleted roster, which may keep total goals on the lower side if their defensive three holds shape, but Arsenal's attacking talent makes the over worth considering. Both teams to score feels like a stretch given Leeds' attacking limitations without Joseph and Tzolis.

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Aston Villa vs Brentford - Saturday, 10:00 AM ET

Predicted Lineup Gameweek 6

Aston Villa: Suzuki; Ruggeri, Lindelof, Mings, Cash; Kamara, Joao Gomes; Buendia, Manzambi, McGinn; Jackson
Brentford: Kelleher; Lewis-Potter, Ajer, Schuster, Kayode; Sangare, Janelt; Schade, Yarmolyuk, Anthony; Igor Thiago

Aston Villa are without Ian Maatsen and Amadou Onana, both listed as out, while Pau Torres, Leon Goretzka and goalkeeper Marco Bizot are all questionable. Zion Suzuki is expected between the posts as a result. Nicolas Jackson leads the line in attack. Brentford have their own concerns, with Nathan Collins, Josh Dasilva, Mathias Jensen, Dango Ouattara and Senne van den Berg all carrying doubtful statuses, though Igor Thiago is predicted to start up front and Caoimhin Kelleher takes the goalkeeping spot.

This looks like a genuinely competitive fixture, with the odds reflecting how close it could be. Both teams are missing important pieces, which creates some unpredictability in terms of shape and output. The both teams to score market is worth a look given each side has attacking options capable of creating chances. Goalscorer angles center on Jackson for Villa and Igor Thiago for Brentford. The moneyline is tough to call with so many doubts, but a draw is not out of the question if key absences disrupt both attacks.

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Chelsea vs Bournemouth - Saturday, 10:00 AM ET

Predicted Lineup Gameweek 6

Chelsea: Martinez; Fofana, Lacroix, Colwill; Chavarria, Caicedo, James, Neto; Palmer, Rogers; Welbeck
Bournemouth: Petrovic; Truffert, Antonio Silva, Hill, Smith; Tyler Adams, Alex Scott; Tavernier, Christie, Rayan; Evanilson

Chelsea come into this fixture with a cluster of high-profile doubts. Moises Caicedo, Reece James and Cole Palmer are all listed as questionable, and if Palmer misses out, Chelsea's creative threat through the middle is considerably reduced. Danny Welbeck is predicted to lead the line. Joao Pedro is also doubtful, while Jonathan Gittens is ruled out entirely. Bournemouth are without Julian Araujo and Elias Kroupi, while Justin Kluivert, Antoine Semenyo's sibling, Amine Adli and David Brooks are all flagged as questionable.

If Palmer is fit, Chelsea remain the clear home favorite with genuine goal threat. His anytime scorer odds are worth monitoring. However, the number of doubts surrounding Chelsea's engine room makes this a trickier moneyline than it might appear. Bournemouth's Evanilson is a reliable goalscorer threat and could be a value pick in the anytime scorer market at attractive odds. Given Chelsea's defensive solidity when healthy, the under could appeal if the midfield doubts disrupt their attacking rhythm, but if Palmer plays, the over has a strong case.

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Ipswich Town vs Fulham - Saturday, 10:00 AM ET

Predicted Lineup Gameweek 6

Ipswich Town: Walton; Davis, O'Shea, Diop, Ouattara; Lukic, Palacios; Philogene, Enciso, Clarke; Emersonn
Fulham: Leno; Robinson, Bassey, Affengruber, Castagne; Berge, Charles; Iwobi, Josh King, Bobb; Gonzalo Garcia

Ipswich are without Abdul Fatawu through suspension, which removes a dangerous attacking option from their right flank. Jack Taylor carries a questionable tag as well. Fulham enter in relatively good health, with only Tom Cairney and Kenny Tete listed as doubts. The Fulham back line of Bassey and Affengruber looks solid, with Bernd Leno expected in goal. Oscar Bobb is predicted to feature on the right for Fulham after his move, adding an interesting creative dimension.

Fulham will be slight favorites or close to it given Ipswich's injury concerns and suspension. The Fulham moneyline is a reasonable parlay piece. For totals, both sides have the attacking personnel to contribute, with Julio Enciso and Jack Clarke providing creativity for Ipswich and Alex Iwobi pulling strings for Fulham. Both teams to score is a decent option here, as Ipswich have enough in attack despite losing Fatawu. Gonzalo Garcia is the Fulham goalscorer to target, while Emersonn leads the line for the hosts.

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Sunderland vs Brighton and Hove Albion - Saturday, 10:00 AM ET

Predicted Lineup Gameweek 6

Sunderland: Roefs; Reinildo, Danso, Alderete, Mukiele; Xhaka, Sadiki; Angulo, Le Fee, Meunier; Isidor
Brighton and Hove Albion: Verbruggen; Boscagli, Dunk, Vuskovic, Kadioglu; Gross, Ayari; De Cuyper, Yalcouye, Diego Gomez; Kostoulas

Sunderland have a handful of concerns with Noah Sadiki carrying a questionable tag despite appearing in the predicted XI, while Habib Diarra and Ryan Mundle are out entirely. Brighton arrive with arguably the longest doubtful list in the gameweek: Yasin Ayari, Lewis Dunk, Jordan Hinshelwood, Mats Wieffer, Kaoru Mitoma, Pascal Struijk, Simon Adingra, Evangelos Pavlidis and Kostoulas are all listed as questionable, with Evan Ferguson and Yankuba Minteh ruled out.

Brighton's extensive doubt list is the key betting angle here. If several of those questionable players are unavailable, their attack loses significant depth, making Sunderland a live underdog at home. The odds reflect genuine uncertainty, with this shaping up as a close contest. For parlay builders, a Sunderland draw no bet or even a Sunderland win could offer value if Brighton's injury situation worsens. Wissam Isidor leading the line for Sunderland gives them a focal point, while Kostoulas, if fit, would anchor Brighton's attack. Both teams to score looks viable given the attacking options on both sides.

Compare Sunderland vs Brighton and Hove Albion odds

Manchester United vs Tottenham Hotspur - Saturday, 12:30 PM ET

Predicted Lineup Gameweek 6

Manchester United: Lammens; Shaw, Maguire, Martinez, Dalot; Tielemans, Mainoo; Rashford, Fernandes, Mbeumo; Cunha
Tottenham Hotspur: Kinsky; Udogie, van Hecke, van de Ven, Gray; Tonali, Bentancur; Marmoush, Kudus, Savio; Solanke

Manchester United carry several notable doubts, with Kobbie Mainoo and Marcus Rashford both questionable, while Manuel Ugarte is ruled out entirely. Amad Diallo is doubtful, reducing United's attacking options off the bench. Benjamin Sesko is also listed as uncertain. Tottenham are without Dejan Kulusevski, Xavi Simons and Wilson Odobert, all of whom are unavailable, while Jakub van Hecke is questionable at center back. Pedro Porro is also ruled out, meaning Archie Gray covers the right flank.

United are slight favorites at home but Tottenham's attacking lineup of Omar Marmoush, Mohammed Kudus and Savio remains dangerous despite the absentees. Dominic Solanke is the primary goalscorer target for Spurs. For United, Bryan Mbeumo is the standout threat and a strong anytime scorer candidate. With both sides carrying doubts in key areas, this feels like a game that could go either way, making the both teams to score market appealing. Bruno Fernandes pulling the strings adds another goalscoring dimension for United. The high-profile nature of the fixture could favor the over on totals.

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Crystal Palace vs Nottingham Forest - Sunday, 9:00 AM ET

Predicted Lineup Gameweek 6

Crystal Palace: Henderson; Richards, Canvot, Ahanor; Mitchell, Timber, Wharton, Khalaili; Pino, Kamada; Strand Larsen
Nottingham Forest: Sels; Milenkovic, Jair Cunha, Murillo; Williams, Schlager, McAtee, Munoz; Gibbs-White, Ndoye; Delap

Crystal Palace face a testing fixture with goalkeeper Dean Henderson listed as questionable, creating uncertainty over who lines up between the posts. Axel Disasi is suspended, and Chadi Riad is ruled out, leaving the Palace backline light. Amine Khalaili and Jean-Philippe Mateta are doubtful, while Takehiro Tomiyasu is also flagged. Nottingham Forest look relatively settled, though Nikola Milenkovic carries a questionable tag at center back and Nedeljko Savona is a doubt as well.

Forest could be considered slight favorites or close to it given Palace's defensive and goalkeeping uncertainty. Liam Delap has been a reliable goalscorer threat and is a strong anytime pick for parlay builders. Morgan Gibbs-White adds further creative danger for Forest. For Palace, Jens Strand Larsen leads the line and remains a viable scorer, while Yeremy Pino adds creativity. The match has the feel of a tight, low-scoring affair given Palace's missing pieces, making the under or a 1-0 correct score an interesting longer-shot option. Both teams to score is possible but uncertain given Palace's depleted attack.

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Hull City vs Everton - Sunday, 9:00 AM ET

Predicted Lineup Gameweek 6

Hull City: Tzolakis; Giles, Ajayi, Egan, Mendy, Coyle; Thomas, Slater, Crooks, Belloumi; McBurnie
Everton: Pickford; Mykolenko, Branthwaite, Tarkowski, Maitland-Niles; Garner, Armstrong; Grealish, Dewsbury-Hall, Johnson; Barry

Hull City are contending with a lengthy injury list, including Nobel Mendy as a doubt despite being listed in the predicted XI in a back five setup. Matt Targett, Brendan Norton-Cuffy, Tatsuhiro Iroegbunam and others are all doubtful, while Jack Butland, Darko Gyabi and Eliot Matazo are ruled out. Everton arrive with Vitaliy Mykolenko questionable at left back, alongside doubts surrounding Christian Norgaard and Merlin Rohl, but the squad looks relatively functional with Jordan Pickford in goal and Jarrad Branthwaite anchoring the defense.

Everton are expected to be favorites away from home here, and the moneyline for the Toffees is a reasonable parlay inclusion. Hull's attacking options are limited with Oli McBurnie as the lone striker, making it harder to see them scoring multiple times. Everton's Jack Grealish provides creative spark, and Timi Barry is the frontman to watch for anytime scorer markets. A low-scoring Everton win or clean sheet for Everton could be angles worth exploring. Both teams to score feels less likely given Hull's attacking limitations and Everton's defensive experience at the back.

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Liverpool vs Manchester City - Sunday, 11:30 AM ET

Predicted Lineup Gameweek 6

Liverpool: Alisson; Kerkez, Jacquet, van Dijk, Araujo; Szoboszlai, Mac Allister; Barcola, Wirtz, Victor Munoz; Isak
Manchester City: Donnarumma; Gvardiol, Guehi, Dias, Matheus Nunes; Fernandez, Anderson; Semenyo, Cherki, Ndiaye; Haaland

Liverpool list Alexander Isak as questionable, which is the headline concern for the hosts. Federico Chiesa and Cody Gakpo are also doubtful, while Conor Bradley and Hugo Ekitike are ruled out. Florian Wirtz and Bradley Barcola add elite quality in the attacking midfield positions regardless. Manchester City will be without Phil Foden, who is suspended, a significant blow to their creative output. Antoine Semenyo is doubtful, while Erling Haaland leads the line and Rayan Cherki is predicted in the number ten role.

This is as close to a coin-flip fixture as the gameweek offers, with the odds reflecting near-equal chances for both sides. If Isak is fit, Liverpool have a dangerous frontline capable of testing City's backline. Haaland remains the standout anytime scorer option regardless of the team sheet and is a fixture in parlay goalscorer legs. For totals, both teams have enough quality to produce goals, making the over an attractive bet. Both teams to score is well worth considering given the elite attacking talent on display. The Foden suspension hurts City's ball progression, which could favor Liverpool in midfield battles.

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Coventry City vs Newcastle United - Monday, 3:00 PM ET

Predicted Lineup Gameweek 6

Coventry City: Rushworth; Mfuni, Thomas, Pinnock; Jay Dasilva, Onyeka, Grimes, van Ewijk; Rudoni, Tchaouna; Thomas-Asante
Newcastle United: Hornicek; Hall, Thiaw, Botman, Dedic; Nico Gonzalez, Miley; Barnes, Wissa, Murphy; Fernandez-Pardo

Coventry are without Haji Wright through suspension and Adan Amenda through injury, while Tola Awoniyi is also suspended. Marko van Ewijk is questionable at right back. Those attacking absences leave Coventry light up front with Bright Thomas-Asante as the predicted striker. Newcastle are managing several doubts, including Amar Dedic, Lewis Miley, Vitor Livramento, Dan Burn and Joelinton, while Andrew Elanga is ruled out entirely. Despite those concerns, Yoane Wissa is predicted to start and gives Newcastle a lively attacking option.

Newcastle come into this as road favorites against a Coventry side dealing with suspensions and injuries in key attacking areas. The Newcastle moneyline is a sensible parlay anchor for Monday's slate. Wissa is a strong anytime scorer candidate, and Harvey Barnes adds a threat from wide. For Coventry, Liam Tchaouna could provide creativity in behind Thomas-Asante. Given Coventry's attacking limitations due to suspensions, the under may have some appeal, and a Newcastle win to nil is worth a look if Coventry's depleted offense struggles to create. Both teams to score seems less certain given Coventry's reduced options in the final third.

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Predicted Lineups Disclaimer

All lineups featured in this article are predictions based on available team news and injury information at the time of writing. Predicted lineups can and do change before official team sheets are released, which typically happens around one hour before kickoff. Always check for the latest updates before placing any bets. Predicted lineup data via RotoWire.

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